Equipment

DOTTIKON's equipment includes

• Small-scale and pilot plant reactors with a total volume of 10 m³ ranging from 15 to 1'000 l in stainless steel, glass-lined, and Hastelloy C22 with pressure filters and centrifuges for separation
• Production equipment with a total volume of 300 m³ and a reactor range of 4'000 to 12'500 l in stainless steel, glass-lined, and Hastelloy C22 as well as pressure filters and centrifuges for separation
• Dedicated equipment for explosives, low-temperature, and continuous processing
• Drying capabilities including a vacuum tray dryer (520 l, Hastelloy C22), paddle dryers (1'000 to 6'000 l in stainless steel and Hastelloy C22), and state-of-the-art spherical dryers (100 to 3'000 l in Hastelloy C22)
• Batch distillation capacity with up to 40 plates under vacuum conditions
• Thin film evaporator

DOTTIKON's facilities are suited to the manufacturing of chemical intermediates and active pharmaceutical ingredients (APIs) in clinical trials, as well as for marketed small-volume APIs. The small-scale facilities are equipped to handle high-potency products.

Experience in over 130 different chemical reactions enable DOTTIKON to deliver new complex organic compounds within weeks instead of months.

The stand-alone facility is coordinated by our pilot plant and is operated by qualified staff dedicated specifically to the unit. The two small-scale plants operate according to cGMP guidelines.

DOTTIKON meets this demand with three stand-alone, fully qualified cGMP pilot/small-scale plants, equipped to handle high-potency products. DOTTIKON has experience in over 130 different chemical reactions and is scaling up over 80 reaction steps per year using its portfolio of core technologies, low-temperature, high-pressure, wet milling, and continuous processing.

DOTTIKON's modular approach to tailor the equipment to specific needs enables these facilities to handle small- to medium-scale production on one hand, and process and technology transfer as well as scale-up to feed our large-scale multipurpose plants on the other hand.

As part of DOTTIKON's full volume range manufacturing and scale-up services, versatile large-scale capabilities are offered for the production of up to several 100 tons per product and year, e.g.

• 300 m³ capacity
• 9 cGMP multipurpose and specialized multi-ton production plants
• Dedicated plants for
  • Nitration (continuous and batch)
  • Explosive materials
  • Hydrogenation and other high-pressure reactions (up to 50 bar)
  • Low-temperature chemistry (down to –100°C)
  • Handling and manufacturing of high-potent compounds
  • Wet milling
  • Drying (50 kg to 3 tons per batch/Hastelloy C22)
  • Active pharmaceutical ingredients (cGMP/Hastelloy)
  • High-temperature incinerator
• Over 100 different chemical reactions

Isolation equipment for small-scale, pilot and large-scale production

• Pressure filters (mobile and fix, clean rooms)
• Inverted bag and peeling Centrifuges (clean rooms)
• Clean rooms (Class 100'000)
• Dedicated filtration rooms
• Containment (endless liners, DoverPac system, Glove Box)

Drying equipment (cGMP)

• Vacuum tray dryer (520 l, Hastelloy C22)
• Spherical dryer (0.1 m³, Hastelloy C22)
• Paddle dryers (1 to 6 m³, stainless steel/Hastelloy C22)
• Spherical dryers (0.1 m³ to 3 m³, Hastelloy C22)

Special equipment

• Fine impact mill
• Jet mill