High purity, non-GMO isosorbide dimethyl ether (CAS 5306-85-4)

  • Non-GMO statement available upon request
  • Drug Master File type IV, "Letter of Access" available upon request
  • Dottisol is a registered trade mark

Solubility enhancer in


  • Self-tanning 
  • Skin whitening
  • Skin cleaning
  • Anti-ageing



  • Pharma grade excipient
  • Accelerated topical delivery of actives
  • Accelerated penetration
  • Formulation and stability enhancer
  • Dental tartar rehydratizing/softening agent
  • Miscible with water
  • Color- and odorless



  • Among best-in-class leaf penetration promoters
  • High water retention rate
  • No phytotoxicity observed


Performance additive in

Various industries

  • Phase transfer reagent 
  • FDA and EU food regulations compliance
  • Water-based formulations
  • Improved adhesive properties


Isosorbide applications

Article on isosorbide as renewable platform for novel applications

Spec. Chem. Mag. 34, 24 (2014)

Scanning electron micrograph of Dottisol® in water spray droplet on cuticular tomato leaf membrane